M-holinomimetiki

The group

Regarding the group reproduce effects mediator parasimpaticescoy nervous system, acetylcholine caused by its interaction with m-holinoretseptorami. M-holinoretseptora localized in all receiving parasympathetic innervaciu at the end postganglionarnah parasimpaticakih fibres. M-holinoretseptora patchy. Interaction with m_1-holinoretseptorami CNS accompanied by the institution, and m_1-retseptorami intramuralnah parasimpaticakih plexus blood-raising glands secreting glands.
Effect activation m_2-holinoretseptorov located in the heart, is a decrease in HR and other functions heart, including conductance.
The most numerous m-holinomimetikov effects resulting from excitation m_3-holinoretseptorov smooth muscles and glands exokrinnah. They are bronhospazm and bronhoreu strengthening secreting glands stomach, the stomach muscle, jelche- and urinary tract. The aceklidina the blood can be used in atony bowel and bladder.
The most relevant aspect farmakodinamiki m-holinomimetikov is their effect on the inner pressure : they improve outflow vnutriglazna liquid, and thus lower inner pressure. This effect is used in the treatment of vnutriglazna hypertension and glaucoma.